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KMID : 0387420130240030309
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Korean Society of Oriental Neuropsychiatry
2013 Volume.24 No. 3 p.309 ~ p.320
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The Mechanism of Lotus Root Extract (LRE) as Neuro-Protective Effect in Alzheimer Disease (AD)
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Hong Seung-Chul
Lee Chia-Hung
Kim Sang-Heon
Lee Jin-Hee
Koo Byung-Su
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Abstract
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Objectives: There is a possibility LRE as remedy in Alzheimer disease (AD), but it’s nerve protection effect and mechanism have to be elucidate. In this research, we applied LRE on $A{\beta}_{25-35}$ 수식 이미지 pre-treated SH-SY5Y cells, to find out the nerve protection effect and mechanism in AD cell model.
Methods: We tried to confirm that effect by experimenting with 20, 50, and $100{\mu}g/ml$ 수식 이미지 concentration of LRE as a medicine. Next experiment, we assessed damage effect which induced $A{\beta}_{25-35}$ 수식 이미지, known to cause AD, on SH-SY5Y cell. In addition, cellular viability test is executed under $H_2O_2$ 수식 이미지 treatment condition in a SH-SY5Y cell.
Results: 1. In $A{\beta}_{25-35}$ 수식 이미지 treated SH-SY5Y cell, LRE exhibited an anti-phosphorylation effect about tau protein, JNK, and IKB. 2. LRE prevent nerve cell apoptosis, which indued $A{\beta}_{25-35}$ 수식 이미지 and oxidative stress, modify JNK engaged synaptic structure and $NF{\kappa}B$ 수식 이미지 induced p75-neurotrophin receptor polymorphism.
Conclusions: We found that LRE prevented oxidative stress-induced cellular destruction, for example, increased SOD activity of $A{\beta}_{25-35}$ 수식 이미지 treated SH-SY5Y cell and reduced toxicity of oxygen free radical. Consequently, the ingredients of LRE have a role as a catalyzer for $A{\beta}_{25-35}$ 수식 이미지 clearance and as scavenger for active oxygen free radical.
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KEYWORD
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Lotus root, Alzheimer disease, SH-SY5Y cell
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